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Synthesis of beta-lactamase activated nitric oxide donors
Xiaoping Tang1, Tingwei Cai, Peng George Wang
1Department of Chemistry, Wayne State University, Detroit, MI 48202, USA.
Bioorganic & Medicinal Chemistry Letters
|May 6, 2003
Abstract:
In order to achieve site specific delivery of NO, we designed conjugates of cephalosporin with NO donors. NO donors such as cupferron and SIN-1 were evaluated as potential choices for conjugates. Cephalosporin conjugated with SIN-1 demonstrated promising beta-lactamase dependent NO releasing ability.