Related Experiment Video
Updated: Sep 26, 2026

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses
Published on: May 5, 2014
Discovery of novel low molecular weight inhibitors of IMPDH via virtual needle screening
Stephen D Pickett1, Bradley S Sherborne, Trevor Wilkinson
1Roche Discovery Welwyn, Broadwater Road, Welwyn Garden City, Herts AL7 3AY, UK. stephen.d.pickett@gsk.com
Abstract:
Novel, low molecular weight inhibitors of IMPDH have been discovered through the application of a validated virtual screening protocol. A series of 21 IMPDH inhibitors were used to validate the docking procedure. Application of this procedure to the selection of compounds for screening from an in-house database resulted in a 50-fold reduction in the size of the screening set (3425 to 74 compounds) and gave a hit-rate of 10% on biological evaluation.

