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Synthesis of fluorinated 1-(3-morpholin-4-yl-phenyl)-ethylamines
Yong-Jin Wu1, Huan He, Li-Qiang Sun
1Department of Neuroscience Chemistry, The Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492, USA. young-jin.wu@bms.com
Bioorganic & Medicinal Chemistry Letters
|May 6, 2003
Abstract:
The synthesis of four (+/-)-fluorinated 1-(3-morpholin-4-yl-phenyl)-ethylamines and an enantioselective approach to these amines through reductive amination are described.