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Non-imidazole heterocyclic histamine H3 receptor antagonists
Wenying Chai1, J Guy Breitenbucher, Annette Kwok
1Johnson & Johnson Pharmaceutical Research and Development L. L. C., 3210 Merryfield Row, San Diego, CA 92121, USA. wchai@prdus.jnj.com
Bioorganic & Medicinal Chemistry Letters
|May 6, 2003
Abstract:
Continued exploration of the SAR around the lead imidazopyridine histamine H(3) antagonist 1 has led to the discovery of several related series of heterocyclic histamine H(3) antagonists. The synthesis and SAR of indolizine, indole and pyrazolopyridine based compounds are now described.