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Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay
Published on: September 14, 2014
Anti-AIDS agents 54. A potent anti-HIV chalcone and flavonoids from genus Desmos
Jiu-Hong Wu1, Xi-Hong Wang, Yang-Hua Yi
1Department of Pharmacy, 306 Hospital of PLA, Beijing 100101, China.
Bioorganic & Medicinal Chemistry Letters
|May 6, 2003
Abstract:
Sixteen flavonoids and their derivatives isolated from Desmos spp. were evaluated for inhibition of HIV replication in H9 lymphocyte cells. 2-Methoxy-3-methyl-4,6-dihydroxy-5-(3'-hydroxy)cinnamoylbenzaldehyde (12) and lawinal (6) demonstrated potent anti-HIV activity with EC(50) values of 0.022 and 2.30 microg/mL and therapeutic indexes of 489 and 45.2, respectively. Compound 12 appears to be an excellent lead for further anti-HIV drug development.

