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Tumor necrosis factor-alpha production-regulating activity of phthalimide derivatives in genetically modified murine

Andrzej Orzeszko1, Witold Lasek, Tomasz Switaj

  • 1Institute of Chemistry, Agricultural University, ul. Nowoursynowska 159c, 02-787 Warsaw, Poland. orzeszkoa@delta.sggw.waw.pl

Farmaco (Societa Chimica Italiana : 1989)
|May 6, 2003
PubMed

The effect of imides, monothioimides, trimellitimides, as well as 5'-deoxy-5'-phthaloylamino-derivatives of azidothymidine on tumor necrosis factor-alpha (TNF-alpha) production by genetically modified murine B78H1 melanoma cells transduced with the gene for human TNF-alpha (B78/TNF) was investigated. It was found that N-(adamant-1-yl)monothiophthalimide (1e) and N-(adamant-2-yl)-monothiophthalimide (1f) showed over 200% enhancing of TNF-alpha production while some of imides were inhibitors.

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