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The Maudsley early onset schizophrenia study: cognitive function in adolescents with recent onset schizophrenia
Eugenia Kravariti1, Robin G Morris, Sophia Rabe-Hesketh
1Section of General Psychiatry, Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, SE5 8AF, London, UK. e.kravariti@iop.kcl.ac.uk
Abstract:
Neuropsychological function has been little studied early in the course of adolescent onset schizophrenia. The present study investigated cognitive function in adolescents with recent onset schizophrenia (n=20) and healthy controls (n=21), employing a comprehensive battery of intelligence, memory and executive function paradigms. Relative to the control group, the patients showed significant or near-significant deficits in more than half of the cognitive variables we examined. A substantial proportion of this broadly based neuropsychological deficit could be accounted for, at least in part, by a mild decrement in general intellectual ability. However, deficits in general and verbal memory remained highly significant after co-varying for IQ.