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IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton
Michael W Briggs1, David B Sacks
1Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Thorn 530, 75 Francis Street, Boston, MA 02115, USA.
Abstract:
A family of proteins known as IQGAPs have been identified in yeast, amebas and mammals. IQGAPs are multidomain molecules that contain several protein-interacting motifs which mediate binding to target proteins. Mammalian IQGAP1 is a component of signaling networks that are integral to maintaining cytoskeletal architecture and cell-cell adhesion. Published data suggest that IQGAP1 is a scaffolding protein that modulates cross-talk among diverse pathways in complex regulatory circuits. These pathways include modulating the actin cytoskeleton, mediating signaling by Rho family GTPases and calmodulin, regulating E-cadherin and beta-catenin function and organizing microtubules.
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