Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Toxicogenetics: applications and opportunities.

George Orphanides1, Ian Kimber

  • 1Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, SK10 4TJ, United Kingdom. george.orphanides@syngenta.com

Toxicological Sciences : an Official Journal of the Society of Toxicology
|May 6, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Provocation of occupational asthma by non-specific irritation and its relevance for the classification of chemicals as respiratory allergens: a case study of methyl methacrylate.

Regulatory toxicology and pharmacology : RTP·2026
Same author

Derivation of a Point of Departure using NAMs for application in Quantitative Risk Assessment of fragrance materials.

Regulatory toxicology and pharmacology : RTP·2026
Same author

Occupational asthma: dust exposure as a contributory factor and implications for classification of respiratory sensitisers.

Regulatory toxicology and pharmacology : RTP·2025
Same author

An extended Reference Chemical Potency List (RCPL) for characterising the performance of New Approach Methodologies (NAMs) in measuring the skin sensitisation potency of fragrance chemicals.

Regulatory toxicology and pharmacology : RTP·2025
Same author

Accurate regulatory classification of chemical respiratory allergens: The case for robust characterisation of causation.

Regulatory toxicology and pharmacology : RTP·2025
Same author

Comment regarding: 'On the solubility of azodicarbonamide in water/DMSO mixtures: an experimental and computational study' (2024), by Macetti <i>et al.</i>

Royal Society open science·2024
Same journal

Molecular Dosimetry of DNA Adducts in Mice Exposed to Ethylene Oxide.

Toxicological sciences : an official journal of the Society of Toxicology·2026
Same journal

Exposure timing is a determinant of fine particulate matter (PM2.5) pulmonary, vascular and metabolic toxicity in male mice.

Toxicological sciences : an official journal of the Society of Toxicology·2026
Same journal

A fond farewell to Jeffrey Peters, editor-in-chief of ToxSci.

Toxicological sciences : an official journal of the Society of Toxicology·2026
Same journal

Aryl hydrocarbon Receptor Nuclear Translocator 2: A Forgotten Per-ARNT-Sim Transcription Factor.

Toxicological sciences : an official journal of the Society of Toxicology·2026
Same journal

ToxMet: a web tool for toxicogenomic data analysis using genome-scale metabolic modeling.

Toxicological sciences : an official journal of the Society of Toxicology·2026
Same journal

T-cell chromatin states reflect individual differences in ex vivo cytokine release and cytotoxicity induced by T-cell engager ERY22 in cynomolgus monkeys.

Toxicological sciences : an official journal of the Society of Toxicology·2026
See all related articles

Individual genetic makeup influences responses to drugs and environmental chemicals. Toxicogenetics explores these genetic variations to understand personalized reactions to toxicants.

Area of Science:

  • Toxicology
  • Pharmacogenomics
  • Genetics

Background:

  • Individual responses to drugs and environmental agents vary significantly.
  • Genetic differences, including genome polymorphisms, underlie these variations.
  • Understanding these differences is crucial for personalized medicine and toxicology.

Purpose of the Study:

  • To introduce toxicogenetics as a field of study.
  • To discuss the applications and implications of toxicogenetics.
  • To highlight the role of genetic variations in toxicant response.

Main Methods:

  • Human genome sequencing.
  • Identification of genome polymorphisms.
  • Analysis of genotype-environment interactions.

Related Experiment Videos

Main Results:

  • Genotype significantly impacts drug efficacy and adverse reactions.
  • Genetic variations explain differential responses to environmental toxicants and allergens.
  • Toxicogenetics provides a framework for understanding individual susceptibility.

Conclusions:

  • Toxicogenetics offers insights into personalized responses to chemicals.
  • This field has significant implications for drug development and environmental health.
  • Further research in toxicogenetics can lead to improved risk assessment and tailored treatments.