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[CD30 (ki-1) antigen expression in acute infectious mononucleosis]
P. Bellissima1, D. Tricoli, S. Platania
1Istituto di Patologia Generale dell'Universita degli Studi di Catania, Italy.
Le Infezioni in Medicina
|May 6, 2003
Summary
Infectious Mononucleosis can mimic lymphomas like large-cell anaplastic lymphoma, Hodgkin's, and non-Hodgkin's lymphoma. CD30 antigen expression requires careful histological differentiation to distinguish it from these cancers.
Area of Science:
- Immunology
- Oncology
- Pathology
Background:
- CD30 (Ki-1) antigen is expressed on T and B lymphocytes and is associated with lymphomas.
- CD30 is also found on T cells in infectious mononucleosis, complicating differential diagnosis.
- Lymphoproliferative disorders and Epstein-Barr virus are linked.
Purpose of the Study:
- To describe a case of acute infectious mononucleosis mimicking lymphoma.
- To discuss the histological differentiation between infectious mononucleosis and CD30-positive lymphomas.
- To examine the relationship between infectious mononucleosis and Epstein-Barr virus-related lymphoproliferative disease.
Main Methods:
- Histological examination of cervical lymphadenopathy.
- Immunohistochemical analysis for CD30 antigen expression.
- Clinical and serological diagnosis of infectious mononucleosis.
Main Results:
- A case of acute infectious mononucleosis presented with cervical lymphadenopathy and histological findings suggestive of large-cell anaplastic lymphoma.
- Atypical immunoblasts expressing CD30 and Reed-Sternberg-like cells were observed.
- Differential diagnosis between infectious mononucleosis and CD30-positive lymphomas was discussed.
Conclusions:
- Infectious mononucleosis can present with histological features that mimic lymphomas, particularly CD30-positive lymphomas.
- Careful histological and clinical evaluation is crucial for accurate diagnosis.
- Understanding the association between Epstein-Barr virus and lymphoproliferative disorders is important.