Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Different noses for different people.

Idan Menashe1, Orna Man, Doron Lancet

  • 1Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot 76100, Israel.

Nature Genetics
|May 6, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Designing a children's health exposomics study protocol: The CHILDREN_FIRST multi-country prospective cohort using multi-omics and personalized prevention approaches.

PloS one·2026
Same author

CrossFilt: a cross-species filtering tool that eliminates alignment bias in comparative genomics studies of primates.

Genome biology·2026
Same author

Beyond the mean: genetic control of gene expression fidelity and dispersion.

bioRxiv : the preprint server for biology·2026
Same author

Biomarkers on the Icy Jovian Moons: Can Europa Also Provide Insights into Life's Origin?

Life (Basel, Switzerland)·2026
Same author

Beyond the baseline: mapping the context-specific regulatory landscape of disease.

Trends in genetics : TIG·2026
Same author

Evolution from Composome to RNA Replicase.

Life (Basel, Switzerland)·2026
Same journal

Multiomics analysis of primary metabolism reveals the genetic basis of nitrogen partitioning modulated by ZmAVT1A-1 in maize.

Nature genetics·2026
Same journal

No evidence of immunosurveillance in mutation-hotspot-driven clonal hematopoiesis.

Nature genetics·2026
Same journal

Near-perfect genome sequencing in medical genetics.

Nature genetics·2026
Same journal

Three decades of cancer genetics.

Nature genetics·2026
Same journal

Advances and challenges of splicing prediction with AI.

Nature genetics·2026
Same journal

Non-coding variant prioritization based on cell type, developmental stage and evolutionary constraint.

Nature genetics·2026
See all related articles

Many human olfactory receptor genes are pseudogenes. This study found a high prevalence of segregating pseudogenes, revealing significant functional diversity within the human genome.

Area of Science:

  • Genomics
  • Human Genetics
  • Olfactory Receptor Research

Background:

  • The human genome contains over 1,000 olfactory receptor genes.
  • More than half of these genes appear to be non-functional pseudogenes.
  • The evolutionary dynamics and population-level variation of these pseudogenes are not well understood.

Purpose of the Study:

  • To investigate the prevalence of recent pseudogene disruptions in human olfactory receptor genes.
  • To determine if these gene disruptions segregate with intact gene forms within human populations.
  • To identify the extent of functional diversity in olfactory receptor genes.

Main Methods:

  • Genotyping of 51 candidate olfactory receptor genes.
  • Analysis of 189 ethnically diverse human subjects.

Related Experiment Videos

  • Investigating the segregation patterns of pseudogenes and intact gene forms.

    • Main Results:

    • An unprecedented prevalence of segregating pseudogenes was identified.
    • Functional population diversity was observed in olfactory receptor genes.
    • This represents one of the most pronounced cases of genetic diversity in the human genome.

    Conclusions:

    • Recent pseudogene disruptions are common in human olfactory receptor genes.
    • Significant functional genetic diversity exists within human populations for these genes.
    • Olfactory receptor gene pseudogenization contributes substantially to human genomic variation.