Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Elastogenesis in healing wounds in bats.

K S Bhangoo, J C Church

    Plastic and Reconstructive Surgery
    |April 1, 1976
    PubMed
    Summary

    Fruit bat web wounds healed with new elastin fibers, mimicking normal tissue structure over six months. This suggests elastin is key to scar elasticity.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Larva therapy in wound management.

    Journal of the Royal Society of Medicine·2000
    Same author

    The traditional use of maggots in wound healing, and the development of larva therapy (biosurgery) in modern medicine.

    Journal of alternative and complementary medicine (New York, N.Y.)·1996
    Same author

    Pelvic abscess after colon and rectal surgery--what is optimal management?

    Diseases of the colon and rectum·1993
    Same author

    Effect of simultaneous administration of betamethasone and triiodothyronine (T3) on the development of functional pulmonary maturation in fetal rabbit.

    Biochemical and biophysical research communications·1987
    Same author

    Pharmacokinetic study of ceftazidime in bone and serum of patients undergoing hip and knee arthroplasty.

    The Journal of antimicrobial chemotherapy·1985
    Same author

    Delayed rupture of renal pseudoaneurysm: complication of percutaneous nephrostomy.

    AJR. American journal of roentgenology·1982

    Area of Science:

    • Biomedical Science
    • Tissue Regeneration
    • Dermatology

    Background:

    • Scar formation involves complex extracellular matrix remodeling.
    • Elastin is a crucial protein for tissue elasticity and integrity.
    • Understanding scar healing in mammals can provide insights into tissue repair.

    Purpose of the Study:

    • To investigate the deposition and organization of elastin during scar healing in a mammalian model.
    • To determine if scar elastin organization replicates normal tissue architecture.
    • To explore the role of elastin in conferring elasticity to healing wounds.

    Main Methods:

    • Full-thickness square wounds were surgically created in the webs of fruit bats.
    • Scar tissue development was monitored over a 6-month period.
    • Histological analysis was performed to examine elastin deposition and organization within the healing scars.

    Main Results:

    • Elastin was deposited in healing scars in two distinct patterns: beneath the regenerated epidermis and as fiber bundles originating from cut web elastin.
    • The newly formed elastin fibers replicated the orientation and origin of the native elastin in the surrounding web.
    • Over 6 months, elastin increased in amount while other scar components decreased.
    • The arrangement of elastin in scar tissue closely resembled that of normal, uninjured web tissue.

    Conclusions:

    • Elastin deposition in fruit bat web scars follows a pattern that restores normal tissue architecture.
    • The study provides evidence that elastin plays a significant role in imparting elasticity to scar tissue.
    • This model demonstrates a potential mechanism for achieving functional elasticity in wound healing.

    Related Experiment Videos