Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Motifs, modules and games in bacteria.

Denise M Wolf1, Adam P Arkin

  • 1Department of Bioengineering, University of California, Physical Biosciences Division, Lawrence Berkeley National Laboratory, Howard Hughes Medical Institute, 1 Cyclotron Road, MS 3-144, Berkeley, CA 94720, USA. dmwolf@lbl.gov

Current Opinion in Microbiology
|May 7, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Peripheral blood transcriptional profiling predicts tumor subtype and neoadjuvant chemoimmunotherapy outcomes in human breast cancer.

Science translational medicine·2026
Same author

The WalRK two-component system in <i>Streptococcus pneumoniae</i> ensures robustness of secondary wall polymer attachment.

bioRxiv : the preprint server for biology·2026
Same author

Origin of replication discovery for environmentally isolated <i>Pantoea</i> strain enables expression of heterologous proteins, pathways and products.

iScience·2026
Same author

KBase: Open-source Platform for Collaborative Biological Data Analysis and Publication.

Journal of molecular biology·2026
Same author

Construction of a randomly barcoded insertional mutant library in the filamentous fungus <i>Trichoderma atroviride</i>.

bioRxiv : the preprint server for biology·2025
Same author

Circulating tumor DNA refines risk stratification of neoadjuvant therapy-resistant breast tumors.

Nature communications·2025

High-throughput sequencing reveals bacterial regulatory networks organized as motifs and modules. This framework helps understand cellular strategies, evolution, and bioengineering applications.

Area of Science:

  • Microbiology
  • Systems Biology
  • Evolutionary Biology

Background:

  • High-throughput sequencing and molecular measurements enable study of bacterial regulatory networks.
  • A conceptual framework is emerging to understand regulation through motifs, modules, and games.
  • Motifs are conserved biological units, organized into functional modules (e.g., cell cycle, stress response).

Purpose of the Study:

  • To explore the dynamics, organization, and evolution of bacterial regulatory networks.
  • To develop a conceptual framework for understanding cellular regulation.
  • To differentiate species-specific adaptations from core physiological functions in an evolutionary context.

Main Methods:

  • Utilizing high-throughput sequencing data.

Related Experiment Videos

  • Analyzing molecular measurements of bacterial physiology.
  • Applying a framework of motifs, modules, and games to regulatory networks.

    • Main Results:

    • Bacterial regulatory networks can be understood through motifs, modules, and games.
    • Module dynamics represent cellular survival strategies in competitive environments.
    • Evolutionary context helps distinguish species-specific traits from core functions.

    Conclusions:

    • The motif-module-game framework provides insights into cellular design and pathway evolution.
    • This approach aids in understanding how bacteria adapt to their environment.
    • It holds promise for advancing cellular bioengineering and understanding fundamental life processes.