Related Experiment Video
Updated: Mar 24, 2026
09:08
Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
Published on: June 2, 2021
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Pathophysiology of human genetic CD36 deficiency
Ken-ichi Hirano1, Takahiro Kuwasako, Yumiko Nakagawa-Toyama
1Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan. khirano@kb3.so-net.ne.jp
Trends in Cardiovascular Medicine
|May 7, 2003
Summary
CD36 deficiency, common in Asian and African populations, may increase risk for cardiovascular diseases like metabolic syndrome and cardiomyopathy. This suggests CD36
Area of Science:
- Cardiovascular Biology
- Molecular Medicine
- Human Genetics
Background:
- CD36 is an integral membrane protein expressed in the cardiovascular system.
- Human genetic CD36 deficiency is prevalent in Asian and African populations.
- CD36 functions as a scavenger receptor for oxidized LDL and a transporter for long-chain fatty acids.
Purpose of the Study:
- To investigate the role of CD36 deficiency in cardiovascular diseases.
- To explore the link between CD36 deficiency and metabolic syndrome.
- To examine the association between CD36 deficiency and cardiomyopathy.
Main Methods:
- Analysis of human genetic CD36 deficiency.
- Investigation of CD36's role in oxidized low-density lipoprotein scavenging.
- Assessment of CD36's function in long-chain fatty acid transport.
Main Results:
- CD36 deficiency is linked to the metabolic syndrome.
- CD36 deficiency may be associated with atherosclerotic cardiovascular diseases.
- CD36 deficiency is potentially linked to cardiomyopathy.
Conclusions:
- CD36 deficiency may be a significant genetic factor in life-threatening cardiovascular diseases.
- Understanding CD36's role is crucial for cardiovascular disease research.
- Genetic variations in CD36 could predispose individuals to cardiovascular conditions.
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