Related Experiment Videos
Intrauterine pathology in women with abnormal uterine bleeding taking hormone replacement therapy
Pui Ling Leung1, Wing Hung Tam, Wing Shan Kong
1Department of Obstetrics and Gynaecology, Prince of Wales Hospital, Chinese University of Hong Kong.
Study Objective:
To assess the frequency of intrauterine pathology among women with abnormal uterine bleeding (AUB) while taking hormone replacement therapy (HRT), and correlate pathology with clinical features.
Design:
Retrospective review (Canadian Task Force classification II-2).
Setting:
University teaching hospital-based outpatient clinic.
Patients:
Ninety-nine women.
Intervention:
Observational evaluation.
Measurements And Main Results:
Intrauterine pathology was found in 16 (18.6%) of 99 women with AUB. The frequency was 4 times higher in those with AUB after achieving amenorrhea with a continuous combined regimen of HRT than in those with AUB with only 6 months of HRT. It was also higher in patients taking a continuous combined regimen in whom AUB lasted for more than 6 months.
Conclusion:
Hysteroscopic examination with endometrial sampling is recommended if AUB continues after the first 6 months of HRT or if it occurs after a period of amenorrhea.