Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Engineering mesenchymal stem cells for immunotherapy.

C Jorgensen1, F Djouad, F Apparailly

  • 1Service d'Immuno-Rhumatologie, Hôpital Lapeyronie, Montpellier, France.

Gene Therapy
|May 7, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Surface modification of extracellular vesicles with polyoxazolines to enhance their plasma stability and tumor accumulation.

Biomaterials·2024
Same author

A cheek lesion.

La Revue de medecine interne·2022
Same author

Development and characterization of a humanized mouse model of osteoarthritis.

Osteoarthritis and cartilage·2022
Same author

Validation of a new fluidic device for mechanical stimulation and characterization of microspheres: A first step towards cartilage characterization.

Materials science & engineering. C, Materials for biological applications·2021
Same author

Identification of TGFβ signatures in six murine models mimicking different osteoarthritis clinical phenotypes.

Osteoarthritis and cartilage·2020
Same author

PPARβ/δ-dependent MSC metabolism determines their immunoregulatory properties.

Scientific reports·2020
Same journal

Improving the precision of AAV lung gene therapy for SP-B deficiency using computationally derived lung-specific promoters.

Gene therapy·2026
Same journal

Recent advancements in improving cross-species applicability of bioengineered AAV capsids.

Gene therapy·2026
Same journal

Assessment of F/HN-pseudotyped lentiviral vector following intravenous delivery to mice.

Gene therapy·2026
Same journal

Applications of genome editing technologies in the treatment of human diseases.

Gene therapy·2026
Same journal

High resolution ES-DMA quantifies AAV capsid DNA content by electrical mobility to mass correlation.

Gene therapy·2026
Same journal

AAV8-mediated mouse/human PROC expression rescues thrombophilia in hereditary protein C-deficient mice.

Gene therapy·2026
See all related articles

Mesenchymal stem cells (MSCs) can induce donor-specific tolerance, aiding organ transplantation and treating autoimmune diseases. Co-injection with MSCs reduces graft-versus-host disease in allogeneic transplantation.

Area of Science:

  • Immunology
  • Transplantation Biology
  • Regenerative Medicine

Background:

  • Allogeneic hematopoietic stem cell transplantation (HSCT) can induce donor-specific tolerance, facilitating organ transplantation.
  • Current applications in autoimmune diseases show susceptibility to recurrence.
  • Mesenchymal stem cells (MSCs) within bone marrow may mediate immunosuppression.

Purpose of the Study:

  • To discuss the therapeutic potential of MSCs in tolerance induction and autoimmune disease treatment.
  • To explore MSCs as immunosuppressive agents or genetically engineered therapeutic tools.

Main Methods:

  • Review of existing literature on HSCT and MSCs in tolerance induction.
  • Discussion of MSCs' role in allogeneic transplantation and graft-versus-host disease reduction.

Related Experiment Videos

  • Exploration of genetic engineering strategies for MSC-based therapies.

    • Main Results:

    • HSCT with MSCs demonstrates potential for inducing donor-specific tolerance.
    • Coinjection of MSCs with hematopoietic grafts is associated with a low incidence of graft-versus-host disease.
    • MSCs show promise as immunosuppressive agents and in engineered therapeutic strategies.

    Conclusions:

    • MSCs are critical for the immunosuppressive effects observed in HSCT-induced tolerance.
    • Therapeutic strategies involving MSCs offer potential for improving allogeneic transplantation outcomes and managing autoimmune diseases.