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Related Experiment Videos

Acute hepatitis induced by kava kava.

C L Humberston1, J Akhtar, E P Krenzelok

  • 1Pittsburgh Poison Center, Children's Hospital of Pittsburgh, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania 15204, USA.

Journal of Toxicology. Clinical Toxicology
|May 8, 2003
PubMed
Summary
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Kava kava, a popular herbal remedy, has been linked to severe liver damage (hepatotoxicity). This case highlights the critical need for healthcare providers to consider herbal product use in unexplained liver injury.

Area of Science:

  • Hepatology
  • Herbal Medicine Safety
  • Toxicology

Background:

  • Kava kava (Piper methysticum) is widely used as an antianxiety and sedative agent.
  • Herbal preparations are often perceived as safe by the public.
  • This report details a case of acute hepatitis potentially linked to kava kava use.

Observation:

  • A 14-year-old female developed acute liver failure requiring a transplant.
  • Liver biopsy revealed hepatocellular necrosis consistent with chemical hepatitis.
  • Extensive work-up excluded other causes of liver failure.

Findings:

  • The patient had a four-month history of using a kava kava-containing product.
  • Causality between kava kava use and liver failure is supported by the clinical presentation, negative work-up, and histological findings.

Related Experiment Videos

  • This case demonstrates kava kava-induced hepatotoxicity.

    • Implications:

    • Healthcare professionals must be aware of kava kava's potential for liver toxicity.
    • Increased vigilance and quality control for herbal products are essential.
    • Inquiring about herbal product intake is crucial for diagnosing unexplained liver injury.