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Pleomorph poorly differentiated endocrine carcinoma of the rectum
Pellegrino Crafa1, Massimo Milione, Cinzia Azzoni
1Department of Pathology and Laboratory Medicine, Section of Anatomic Pathology, University of Parma, 43100, Parma, Italy.
Abstract:
We present a case of poorly differentiated endocrine carcinoma (PDEC) of the rectum identified immunohistochemically and characterized by a high degree of cellular pleomorphism, including bizarre giant cells. This case indicates that gastrointestinal PDECs are not restricted to small cell carcinomas. Among the multiple genes investigated, loss of heterozygosity (LOH) of the p53 locus without p53 immohistochemical accumulation, overexpression of c-kit and absent expression of p16 were seen.