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Systems toxicology and the Chemical Effects in Biological Systems (CEBS) knowledge base
Michael Waters1, Gary Boorman, Pierre Bushel
1National Center for Toxicogenomics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. waters2@niehs.nih.gov
EHP Toxicogenomics : Journal of the National Institute of Environmental Health Sciences
|May 9, 2003
Summary
The Chemical Effects in Biological Systems (CEBS) knowledge base integrates diverse molecular and toxicological data to advance systems toxicology. This resource aids in understanding chemical impacts on organisms, improving drug safety and environmental risk assessment.
Area of Science:
- Toxicogenomics and Systems Biology
- Environmental Toxicology and Human Disease Research
Background:
- The National Center for Toxicogenomics is creating a novel public toxicogenomics knowledge base.
- Existing data is fragmented across transcriptomics, proteomics, metabonomics, and toxicology fields.
Purpose of the Study:
- To develop the Chemical Effects in Biological Systems (CEBS) knowledge base.
- To integrate molecular expression data with pathway and network information.
- To support systems toxicology research for environmental health and disease.
Main Methods:
- Combining data from transcriptomics, proteomics, metabonomics, and conventional toxicology.
- Assembling relational and descriptive compendia for genes, SNPs, and phenotypes.
- Utilizing functional genomics approaches and assimilating data from public databases.
Main Results:
- CEBS will be searchable by compound, gene, pathway, and phenotype, across dose and time.
- Researchers can query CEBS using transcriptomes to find compounds with similar response profiles.
- The knowledge base will link chemical exposure to biological responses and toxicological outcomes.
Conclusions:
- CEBS will serve as a crucial resource for hypothesis-driven and discovery research.
- The knowledge base aims to enhance drug safety evaluations.
- CEBS will improve the accuracy of risk assessments for environmental chemicals.