Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Current perspectives on anal cancer.

Johanna C Bendell1, David P Ryan

  • 1Massachusetts General Hospital Cancer Center, Boston, Massachusetts, USA.

Oncology (Williston Park, N.Y.)
|May 9, 2003
PubMed
Summary

Anal cancer, linked to human papillomavirus, is now treatable with combined radiation and chemotherapy, preserving the anal sphincter. Research explores new chemotherapy agents and screening for high-risk groups.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of Liver Metastases on Survival in Microsatellite-Stable Metastatic Colorectal Cancer Treated with Immune Checkpoint Inhibitors.

Cancer research communications·2026
Same author

High frequency DOC proxy sensor assessment for peatland streams and across hydrological continua.

Journal of environmental management·2025
Same author

Academic Medical Centers and ASCO Recommendations: Starting a Difficult Discussion.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2025
Same author

Severe Lymphopenia Predicts Poorer Survival in Patients With Rectal Cancer Undergoing Neoadjuvant Chemoradiation.

Cancer journal (Sudbury, Mass.)·2025
Same author

Long-term Outcomes of Definitive Chemoradiation With Proton Therapy for Treatment of Carcinoma of the Anal Canal: Combined Analysis of Two Prospective Trials.

International journal of radiation oncology, biology, physics·2025
Same author

First Results of Migoprotafib, a Potent and Highly Selective Src Homology-2 Domain-Containing Phosphatase 2 Inhibitor in Patients with Advanced Solid Tumors.

Molecular cancer therapeutics·2024

Area of Science:

  • Oncology
  • Gastroenterology
  • Epidemiology

Background:

  • Anal cancer represents 1.5% of US digestive system malignancies.
  • Historically, it was attributed to local inflammation, treated with abdominoperineal resection.
  • Current understanding links anal cancer development to human papillomavirus (HPV) infection, similar to cervical cancer.

Purpose of the Study:

  • To review the progress in understanding anal cancer pathophysiology and treatment.
  • To highlight the shift from surgical resection to less invasive, organ-preserving therapies.
  • To discuss current research directions in anal cancer management.

Main Methods:

  • Review of epidemiologic and clinical studies on anal cancer.
  • Analysis of treatment outcomes for concurrent chemoradiation therapy.
  • Examination of ongoing research in chemotherapy and screening.

Main Results:

  • Anal cancer development is strongly associated with HPV infection.
  • Concurrent external-beam radiation therapy with fluorouracil (5-FU)/mitomycin chemotherapy offers high cure rates.
  • This combined treatment allows for anal sphincter preservation in most patients.

Conclusions:

  • Modern treatment paradigms for anal cancer have significantly improved outcomes.
  • HPV is a key factor in anal cancer etiology.
  • Future research focuses on enhancing chemotherapy regimens and implementing targeted screening for high-risk populations.

Related Experiment Videos