Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Citrobacter freundii septicemia in two dogs.

Jean-René Galarneau1, Mado Fortin, Jean-Martin Lapointe

  • 1Département de Pathologie et Microbiologie, Faculté de Médecine Vétérinaire, Université de Montréal, St-Hyacinthe, Québec J2S 7C6, Canada.

Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
|May 9, 2003
PubMed
Summary

Citrobacter freundii caused septicemia in a puppy and an adult dog. This gram-negative bacteria may lead to severe illness, particularly in young or immunocompromised canines, with the gastrointestinal tract as a likely entry point.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A first-in-human phase 1 clinical study in healthy volunteers to assess the safety, tolerability and pharmacokinetics of EDI048, a novel promising agent to treat enteric cryptosporidiosis.

The Journal of infectious diseases·2026
Same author

Discovery of IID432 for Chagas Disease: A Cyanotriazole Inhibitor of <i>Trypanosoma cruzi</i> Topoisomerase II Achieves Sterile Cure After Short-Term Treatment in a Chronic Infection Model.

Journal of medicinal chemistry·2026
Same author

Targeting α v β 8 Integrin with mAb MEDI8367 Prevents Fibrosis in Preclinical Models of CKD.

Kidney360·2025
Same author

Double-Stranded RNA Induces Retinal Pigment Epithelium Cell Degeneration and Inflammation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2025
Same author

A comprehensive welfare scoring system for graft versus host disease clinical assessment in humanised mouse models used for pharmaceutical research.

Frontiers in immunology·2025
Same author

Cryptosporidium PI(4)K inhibitor EDI048 is a gut-restricted parasiticidal agent to treat paediatric enteric cryptosporidiosis.

Nature microbiology·2024

Area of Science:

  • Veterinary Pathology
  • Microbiology
  • Canine Infectious Diseases

Background:

  • Septicemia, a serious bloodstream infection, can affect dogs.
  • Citrobacter freundii is a gram-negative bacterium that can cause infections.

Observation:

  • A Maltese puppy and a Collie dog presented with septicemia linked to Citrobacter freundii.
  • The puppy experienced weakness and mucohemorrhagic diarrhea before succumbing.
  • The Collie developed immune-mediated hemolytic anemia and thrombocytopenia, leading to euthanasia.

Findings:

  • Gross examination revealed hemorrhagic gastrointestinal contents in the puppy and similar findings along with hepatitis, peritonitis, and pneumonia in the Collie.
  • Histopathology showed histiocytic meningitis in the puppy and fibrinonecrotic hepatitis in the Collie.

Related Experiment Videos

  • Gram-negative rods, identified as Citrobacter freundii, were present in lesions in both dogs.

    • Implications:

    • Citrobacter freundii can be a cause of monomicrobic bacteremia-septicemia in dogs, especially in puppies and immunocompromised adults.
    • The gastrointestinal tract is suggested as the primary route of infection.
    • This highlights the importance of recognizing Citrobacter freundii as a potential pathogen in canine sepsis.