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Related Experiment Videos

Lidocaine intoxication: two fatal cases.

Sang-Ki Lee1, Soo-Yeun Lee, Sang-Whan In

  • 1National Institute of Scientific Investigation, Seoul 158-707, Korea. skleedoc@nisi.go.kr

Archives of Pharmacal Research
|May 9, 2003
PubMed
Summary
This summary is machine-generated.

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Acute lidocaine poisoning caused two fatalities: a father and his daughter. Gas chromatography confirmed lethal lidocaine concentrations in postmortem tissues, highlighting the drug's toxicity.

Area of Science:

  • Forensic Toxicology
  • Analytical Chemistry

Background:

  • Lidocaine is a common local anesthetic and antiarrhythmic drug.
  • Acute toxicity can occur with excessive dosing or impaired metabolism.

Observation:

  • Two fatal cases involving a 41-year-old male and his 8-year-old daughter are presented.
  • Both cases resulted from acute lidocaine poisoning.

Findings:

  • Lidocaine concentrations were quantified using gas chromatography (GC) with nitrogen-phosphorus detection.
  • Case 1 (male) showed liver: 27.7 µg/g, spleen: 70.1 µg/g, gastric contents: 23.6 µg/g.
  • Case 2 (daughter) showed liver: 24.9 µg/g, spleen: 29.9 µg/g, gastric contents: 42.8 µg/g.

Implications:

  • These findings underscore the potential for fatal lidocaine poisoning.

Related Experiment Videos

  • Accurate toxicological analysis is crucial for determining cause of death.
  • Highlights the importance of safe lidocaine administration and monitoring.