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Recent advances in antimicrobial nucleoside antibiotics targeting cell wall biosynthesis
Ken-ichi Kimura1, Timothy D H Bugg
1Department of Agro-Bioscience, Iwate University, Iwate 020-8550, Japan.
Natural Product Reports
|May 9, 2003
Abstract:
The biosynthesis of peptidoglycan is essential for all bacteria and has no counterpart in eukaryotic cells. It is one of the prime targets for antibiotic chemotherapy, especially phospho-MurNAc-pentapeptide translocase (translocase I) is a fascinating target in which there is no commercial antibiotic. In this review we will describe three nucleoside translocase I inhibitors, mureidomycin, tunicamycin and liposidomycin.