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Trimethylsilyl halide-promoted Michaelis-Arbuzov rearrangement
Pierre-Yves Renard1, Philippe Vayron, Charles Mioskowski
1Service de Marquage Moléculaire et de Chimie Bioorganique, CEA Saclay, F-91191 Gif sur Yvette Cedex, France. pierre-yves.renard@cea.fr
Organic Letters
|May 9, 2003
Abstract:
[reaction: see text] We describe a new, straightforward, and easy-to-handle method for achieving an unprecedented trimethylsilyl halide-catalyzed Michaelis-Arbuzov-like rearrangement. This rearrangement occurs at temperatures from room temperature to 80 degrees C and does not require addition of any alkyl halide. The scope and limitations of this new reaction are explored, as well as its mechanism.