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Palladium-catalyzed synthesis of novel optically active tryptophan analogues
Bart C J van Esseveldt1, Floris L van Delft, René de Gelder
1Departments of Organic and Inorganic Chemistry, NSRIM, University of Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands.
Organic Letters
|May 9, 2003
Abstract:
[reaction: see text] Both unsaturated proline derivatives and optically active tryptophan analogues have been obtained via Pd-catalyzed cyclization of aniline-containing acetylenic amino acids. The side chain length of the cyclization precursor determines which one of the two possible products will be formed.