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Total synthesis of debromoflustramine B via biomimetic alkylative cyclization
Gan Hup Tan1, Xiuwen Zhu, A Ganesan
1Department of Chemistry, University of Southampton, Southampton SO17 1BJ, United Kingdom.
Organic Letters
|May 9, 2003
Abstract:
[reaction: see text] The hexahydropyrrolo[2,3-b]indoline skeleton is readily accessed by the zinc triflate-mediated alkylation of tryptamine derivatives. The methodology was employed in a three-step total synthesis of debromoflustramine B.