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Related Experiment Videos

IVF: past and future.

Howard W Jones1

  • 1Eastern Virginia Medical School, Norfolk, Virginia, USA. joneshw@evms.edu

Reproductive Biomedicine Online
|May 9, 2003
PubMed
Summary
This summary is machine-generated.

In vitro fertilization (IVF) in the New World began in 1965, leading to the first successful birth in 1978. Ovarian stimulation studies revealed three response patterns and discovered the LH surge inhibiting factor.

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Area of Science:

  • Reproductive Medicine
  • In Vitro Fertilization (IVF)

Background:

  • The foundational work for New World in vitro fertilization (IVF) began with Robert Edwards' 1965 fellowship at Johns Hopkins.
  • Initial attempts at human oocyte fertilization in vitro, though not definitively claimed in 1965 publications, are supported by retrospective photographic evidence.

Observation:

  • The first successful term birth via IVF in 1978 spurred the establishment of an IVF clinic in Norfolk, Virginia.
  • Ovarian stimulation in 1981 led to the first New World delivery and subsequent studies on its effects on the menstrual cycle.

Findings:

  • Ovarian stimulation was found to result in three distinct response patterns: high, normal, and low.
  • A key finding was the absence of the luteinizing hormone (LH) surge during ovarian stimulation, leading to the discovery of the LH surge inhibiting factor.

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Implications:

  • The Norfolk IVF program engaged with societal impacts, including ethical discussions at the Vatican and with the American Fertility Society.
  • The research contributed to understanding ovarian stimulation and hormonal regulation in assisted reproductive technologies.