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Synthesis and antihyperglycemic activity of suitably functionalized 3H-quinazolin-4-ones
Vishnu Ji Ram1, Farhanullah, Brajendra K Tripathi
1Division of Medicinal Chemistry, Central Drug Research Institute, 226001, Lucknow, India. vjiram@yahoo.com
Bioorganic & Medicinal Chemistry
|May 9, 2003
Abstract:
A series of 2-sec-amino-3H-quinazolin-4-ones (4a-p) and 4-sec-amino-2-chloroquinazolines (5a-b) have been synthesized by nucleophilic substitution reaction of 2-chloro-4(3H)-quinazolones (3) and 2,4-dichloroquinazolines (2) with amines, respectively. Most of the synthesized compounds were evaluated for antihyperglycemic activity but only 4a,b,d,j,o displayed significant reduction in blood glucose level in streptozotocin and sucrose loaded rat models.