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Water-soluble porphyrins appending platinum(II) complexes as binders for synthetic nucleic acid polymers
Hiroki Munakata1, Hiroyasu Imai, Shigeo Nakagawa
1Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan. h-munakata@hokuriku-u.ac.jp
Chemical & Pharmaceutical Bulletin
|May 9, 2003
Abstract:
Water-soluble porphyrins containing four platinum(II) complexes per molecule, [5alpha,10beta,15alpha,20beta-tetrakis(2-trans-(alpha,beta,alpha,beta-trans-Pt) and cis-(alpha,beta,alpha,beta-cis-Pt) [PtCl(NH(3))(2)]N-2-aminophenylporphyrin)], were synthesized and characterized. The binding of synthetic nucleotide polymers (poly(dG)-poly(dC), poly(dA)-poly(dT)) to the porphyrins was examined spectrophotometrically in aqueous solution. UV-vis spectral data suggested that these porphyrins bind to the nucleic acids by coordinative and Coulomb interactions.