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Lactic dehydrogenase isoenzyme in cerebrospinal fluid of children with infantile spasms

Moshe Nussinovitch1, Daniella Harel, Tali Eidlitz-Markus

  • 1Department of Pediatrics C, Schneider Children's Medical Center of Israel, Petah Tikva, Israel. nussim@clalit.org.il

European Neurology
|May 9, 2003
PubMed

Insights

Infantile spasms in children are linked to a unique lactic dehydrogenase (LDH) isoenzyme pattern in cerebrospinal fluid (CSF). This finding suggests specific LDH changes may indicate infantile spasms.

Area of Science:

  • Neurology
  • Biochemistry

Background:

  • Lactic dehydrogenase (LDH) levels in cerebrospinal fluid (CSF) can indicate intracranial pathologies.
  • Understanding LDH isoenzyme patterns may offer insights into specific neurological conditions.

Purpose of the Study:

  • To investigate the LDH isoenzyme profile in the CSF of infants diagnosed with infantile spasms.
  • To compare these profiles with those of healthy children to identify potential biomarkers.

Main Methods:

  • CSF samples were collected from 12 infants with infantile spasms (4-9 months old) and 15 healthy children.
  • Total LDH activity and LDH isoenzyme percentages were analyzed in all CSF samples.

Main Results:

  • Infantile spasms patients showed a statistically significant lower percentage of LDH-1 (p < 0.01) and a higher percentage of LDH-3 compared to controls.
  • Mean total LDH activity in CSF was 34.62 +/- 6.52 U/l.
  • LDH-4 and LDH-5 percentages were similar between the infantile spasms group and the control group.

Conclusions:

  • Infantile spasms are associated with a distinct LDH isoenzyme pattern in CSF, characterized by reduced LDH-1 and elevated LDH-3.
  • Further research is required to confirm the increase in LDH-2 and LDH-3 and to establish optimal timing for CSF analysis.

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