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Related Experiment Videos

Controlled vesicle deformation and lysis by single oscillating bubbles.

Philippe Marmottant1, Sascha Hilgenfeldt

  • 1Faculty of Applied Physics, University of Twente, PO Box 217, 7500AE Enschede, The Netherlands. p.marmottant@tn.utwente.nl

Nature
|May 9, 2003
PubMed
Summary
This summary is machine-generated.

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Gentle bubble oscillations, not violent collapse, can rupture cell membranes. This discovery opens new avenues for controlled microacoustics in cell manipulation and therapies.

Area of Science:

  • Acoustics
  • Biophysics
  • Cell Biology

Background:

  • Collapsing bubbles concentrate energy, driving phenomena like cavitation damage and sonochemistry.
  • Ultrasound-triggered microbubbles enhance medical imaging and show potential for sonoporation-based therapies.
  • The precise mechanism of bubble-induced membrane rupture in sonoporation remains unclear.

Purpose of the Study:

  • To investigate the mechanism of bubble-induced lipid membrane rupture.
  • To demonstrate that gentle bubble oscillations can achieve membrane rupture.
  • To explore the potential of controlled microacoustics for cell manipulation.

Main Methods:

  • Experiments utilizing controlled, linear oscillations of microbubbles.
  • Observation and analysis of bubble dynamics and subsequent lipid membrane rupture.

Related Experiment Videos

  • Application of microbubbles as acoustic focusing agents at the micrometer scale.

    • Main Results:

    • Gentle, linear bubble oscillations are sufficient to induce lipid membrane rupture.
    • Bubble dynamics and sonoporation can be precisely controlled in this gentle oscillation regime.
    • Microacoustics, leveraging microbubbles, is demonstrated as a viable tool for precise manipulation.

    Conclusions:

    • Sonoporation can be achieved through controlled, gentle bubble oscillations, not solely violent collapse.
    • Microacoustics offers a controllable method for cell membrane permeation and manipulation.
    • This research paves the way for novel therapeutic and microfluidic applications.