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Updated: Aug 16, 2026

Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli
Published on: September 25, 2016
[Chromogenic substrate as antidote against the thrombin inhibitor Melagatran?]
I Bodendiek1, S Lentz, M Seeger
1I. Medizinische Universitätsklinik Kiel, Schittenhelmstrasse 12, 24105 Kiel.
Abstract:
It could be shown in vitro that a chromogenic substrate (Chromozym TH, Roche Mannheim) acts at least partially as antidote against the new thrombin inhibitor Melagatran (AstraZeneca, Mölndal, Sweden). It is discussed that this antidote effect of a chromogenic substrate might be due to a substrate competition of fibrinogen, thrombin inhibitor, and chromogenic substrate for thrombin. Further animal experiments will clarify whether this in vitro observation is of practical relevance in vivo, too.
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