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Updated: Aug 14, 2026

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
Published on: February 14, 2014
Dorsolateral prefrontal lobe activation declines significantly with age--functional NIRS study
Ingrid L Kwee1, Tsutomu Nakada
1Department of Neurology, University of California, Davis, VANCHCS, 150 Muir Road, Martinez, CA 94553, USA. ilkwee@ucdavis.edu
Abstract:
Dorsolateral prefrontal cortex (DLPF) activation in response to cognitive paradigms engaging working memory was quantitatively evaluated using functional near infrared spectroscopy (fNIRS) in cognitively normal individuals across the age spectrum (20-90 years; 8 females, 52 males). DLPF activation score (DAS) demonstrated a significant decline (r(2) = -0561, p < 0.05) as a function of age. The study indicates that blood flow response associated with DLPF activation declines as a function of age in cognitively normal individuals and that fNIRS can be used as a convenient, portable tool for assessing such activation.
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