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Related Experiment Videos

Nitric oxide as an activity marker in multiple sclerosis.

G Acar1, F Idiman, E Idiman

  • 1Department of Neurology, Dokuz Eylül University, School of Medicine, Izmir, Turkey.

Journal of Neurology
|May 9, 2003
PubMed
Summary

Nitric oxide (NO) levels in cerebrospinal fluid are higher during multiple sclerosis (MS) relapses and correlate with disease activity markers. This suggests NO may serve as a potential biomarker for MS relapses.

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Area of Science:

  • Neuroscience
  • Immunology
  • Biochemistry

Background:

  • Nitric oxide (NO) plays a significant role in the pathogenesis of multiple sclerosis (MS).
  • Elevated levels of NO metabolites in cerebrospinal fluid (CSF) and serum of MS patients during relapse may contribute to myelin and oligodendroglial damage.

Purpose of the Study:

  • To investigate if nitric oxide (NO) serves as a marker for multiple sclerosis (MS) disease activity.
  • To assess the correlation between NO levels and other MS disease activity markers, including active brain lesions on MRI and elevated immunoglobulin G (IgG) index.

Main Methods:

  • Collected cerebrospinal fluid (CSF) and peripheral serum (PS) samples from MS patients (n=24) during relapse and remission, and from control subjects (n=18).
  • Measured nitric oxide (NO) metabolites (nitrite and nitrate) using the Griess reaction.

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  • Performed cranial MRI with gadolinium contrast and determined the IgG index.

    • Main Results:

    • CSF nitrite and nitrate concentrations (NNCs) were significantly higher in MS patients during relapse compared to remission and control groups (p=0.000).
    • Serum NNCs were higher in MS patients than in controls, but did not significantly differ between relapse and remission phases.
    • CSF NNC measurements showed 71% specificity and 66% sensitivity for MS disease activity.
    • Increased CSF NNCs significantly correlated with the presence of active brain lesions on MRI and elevated IgG index (p < 0.05).

    Conclusions:

    • The findings support a potential role for nitric oxide (NO) in the pathogenesis of multiple sclerosis (MS).
    • Elevated CSF NNCs during relapse, correlating with MRI activity and IgG index, suggest NO may be a valuable biomarker for MS disease activity.