Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Splenectomy and myelofibrosis.

P Jacobs

    South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
    |March 27, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Splenectomy in myelofibrosis patients can rapidly worsen liver function, leading to fatal complications like ascites and jaundice. Early recognition of this splenic surgery complication is crucial for timely intervention.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Nitric oxide expression in the spleen, but not in the liver, correlates with resistance to blood-stage malaria in mice.

    Journal of immunology (Baltimore, Md. : 1950)·1995
    Same author

    Blunted erythropoietin response to anaemia in tuberculosis.

    European journal of haematology·1995
    Same author

    Immune response of mice infected with Schistosoma mansoni is modulated by antifibrotic treatment.

    Annals of tropical medicine and parasitology·1995
    Same author

    Bone marrow failure. Pathophysiology and management.

    The Central African journal of medicine·1995
    Same author

    A comparison of intensive care unit utilization in Alberta and western Massachusetts.

    Critical care medicine·1995
    Same author

    Role of macrophage-derived nitric oxide in suppression of lymphocyte proliferation during blood-stage malaria.

    Journal of leukocyte biology·1995
    Same journal

    SAMA Health Summit Abstracts.

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
    Same journal

    On behalf of the South African Medical Association (SAMA), The Scientific Committee of the SAMA Health Summit, is pleased to pesent this abstract issue, showcasing the posters and oral presentations delivered at the Summit, which was held from 22-24 May 2026.

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
    Same journal

    Proceedings of the 2<sup>nd</sup> Data Driven Surgery Conference (DDSC 2025).

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
    Same journal

    Clinical practice guidelines for the management of fever and neutropenia in South African children and adolescents with cancer.

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
    Same journal

    The changing fortunes of the District Health System in SA (1994 - 2020): A retrospective review.

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
    Same journal

    Thomas Micheal Guntram Ignaz Rehle (1951 - 2025).

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
    See all related articles

    Area of Science:

    • Hematology
    • Oncology
    • Gastroenterology

    Background:

    • Myelofibrosis is a bone marrow disorder characterized by fibrosis and extramedullary hematopoiesis.
    • Splenectomy is sometimes performed to manage complications of myelofibrosis, such as massive splenomegaly.

    Observation:

    • Two patients with myelofibrosis experienced rapid liver function decline post-splenectomy.
    • The liver deterioration manifested as refractory ascites and worsening jaundice.

    Findings:

    • Ectopic hematopoiesis in the liver was confirmed via liver biopsy.
    • This hepatic involvement contributed to the observed clinical deterioration.

    Implications:

    • Splenectomy in myelofibrosis carries a risk of precipitating severe liver dysfunction due to ectopic hematopoiesis.

    Related Experiment Videos

  • Radiotherapy or cytotoxic chemotherapy may offer potential therapeutic strategies for managing hepatic hematopoiesis post-splenectomy.