Microbial transformation of dehydroepiandrosterone
Related Experiment Video
Updated: Sep 26, 2026

Murine Prostate Micro-dissection and Surgical Castration
Published on: May 11, 2016
M Iqbal Choudhary1, S Adnan Ali Shah, S Ghulam Musharraf
1H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan.
Abstract:
Transformation of dehydroepiandrosterone (DHEA) (1) was carried out by a plant pathogen Rhizopus stolonifer, which resulted in the production of seven metabolites. These metabolites were identified as 3beta,17beta-dihydroxyanandrost-5-ene (2), 3beta,17beta-dihydroxyandrost-4ene (3), 17beta-hydroxyandrost-4-ene-3-one (4), 3beta,11-dihydroxyandrost-4-ene-17-one (5), 3beta,7alpha-dihydroandrost-5-ene-17-one (6), 3A,7alpha,17beta-trihydroxyandrost-5-ene (7) and 11beta-hydroxyandrost-4,6-diene-3,17-dione (8). The structures of the transformed products were determined by the spectroscopic techniques.
Related Concept Videos
Microbial Bioremediation of Pesticides
Microbial Bioremediation of Uranium
Forced Transdifferentiation
Artificial transdifferentiation occurs...
Phase II Reactions: Methylation Reactions
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
Microbial Bioremediation of Hydrocarbons
Microbes and Methanogenesis

