Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Estrogen and neurodegeneration.

Sam Gandy1

  • 1Faber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania 19107-5587, USA. Sam.Gandy@mail.tju.edu

Neurochemical Research
|May 10, 2003
PubMed
Summary

Estrogen, known for reproductive functions, also protects the central nervous system (CNS). Menopause-related estrogen deprivation may increase susceptibility to neurodegenerative diseases and cognitive decline.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endogenously generated Dutch-type Aβ non-fibrillar aggregates dysregulate presynaptic neurotransmission in the absence of detectable inflammation.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Real-world clinical profile of individuals with cerebrospinal fluid Aβ<sup>-</sup>/pTau181<sup></sup>.

Journal of Alzheimer's disease : JAD·2026
Same author

Golgi Fragmentation as a Potential Link Between SARS-CoV-2 Infection and Alzheimer's Disease: Mechanisms and Implications for Neurodegeneration in Long COVID.

Sub-cellular biochemistry·2026
Same author

Differential downstream signaling in microglia lacking Alzheimer's-related TREM2 or its adaptor TYROBP/DAP12.

Molecular neurodegeneration advances·2026
Same author

miR155 triplicated in Down syndrome regulates hippocampal GABAergic neurogenesis in Alzheimer's disease.

bioRxiv : the preprint server for biology·2025
Same author

Characterization of human cytomegalovirus infection dynamics in human microglia.

The Journal of general virology·2025

Area of Science:

  • Neuroscience
  • Endocrinology
  • Gerontology

Background:

  • Estrogen's primary roles in sexual organ maturation are well-established.
  • Emerging evidence highlights estrogen's significant influence within the central nervous system (CNS).
  • Menopause-induced estrogen deprivation is increasingly linked to neurological vulnerability.

Purpose of the Study:

  • To explore estrogen's neuroprotective potential.
  • To investigate the impact of estrogen deprivation on brain health.
  • To understand estrogen's role in cognitive decline associated with aging and disease.

Main Methods:

  • Review of existing literature on estrogen's CNS effects.
  • Analysis of proposed mechanisms of estrogen neuroprotection.
  • Correlation of estrogen deprivation with neurodegenerative processes.

Main Results:

  • Estrogen exhibits neuroprotective properties at multiple levels.
  • Estrogen deprivation exacerbates brain insults, particularly oxidative stress.
  • Reduced estrogen impairs synaptic connectivity and cholinergic integrity.

Conclusions:

  • Estrogen plays a crucial role in maintaining brain health and cognitive function.
  • Menopause-associated estrogen loss significantly increases the risk of neurodegeneration.
  • Targeting estrogen pathways may offer therapeutic strategies for cognitive decline.

Related Experiment Videos