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Hypodysfibrinogenemia during pregnancy, labor, and delivery
Shad H Deering1, Helain J Landy, Nana Tchabo
1Department of Obstetrics and Gynecology, Georgetown University Hospital, Washington, DC 20007, USA. deering95@hotmail.com
Background:
Hypodysfibrinogenemia is an autosomally dominant disorder that can result in excessive bleeding as well as specific pregnancy complications. Increased risks of spontaneous abortion, postpartum hemorrhage, poor wound healing, and placental abruption have been reported.
Case:
A woman with hypodysfibrinogenemia presented for care in the first trimester. Her antepartum course was uncomplicated, and she was administered intermediate-purity factor VIII during labor and did not have excessive bleeding postpartum. The infant's cord fibrinogen was low, at 43 mg/dL (normal 215 +/- 30), showing it was similarly affected.
Conclusion:
Pregnancy in patients with hypodysfibrinogenemia can be associated with various complications; however, coordination of care and anticipation of specific problems can result in a successful outcome for both mother and infant.