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Eosinophilia and uterine leiomyosarcoma
Lubna Pal1, Vinita Parkash, J T Chambers
1Department of Gynecology, Yale University & School of Medicine, Yale New Haven Hospital, New Haven, Connecticut, USA. lubnapal@hotmail.com
Obstetrics and Gynecology
|May 10, 2003
Summary
Systemic eosinophilia can indicate underlying malignancy, as seen in this case of uterine leiomyosarcoma. Surgical removal of the tumor resolved the blood and tissue eosinophilia, highlighting a crucial diagnostic link.
Area of Science:
- Gynecologic Oncology
- Hematology
- Pathology
Background:
- Tumor-associated eosinophilia (blood and tissue) is linked to various cancers.
- Uterine leiomyosarcoma is a rare uterine malignancy.
Observation:
- A postmenopausal woman presented with postmenopausal bleeding and elevated eosinophils.
- Endometrial biopsy revealed atypical mesenchymal tissue with eosinophilic infiltrate, suspicious for sarcoma.
- Preoperative labs showed leukocytosis and eosinophilia.
Findings:
- Histopathology confirmed a low-grade uterine leiomyosarcoma confined to the uterus.
- The tumor showed extensive infiltration by eosinophils.
- Surgical tumor removal led to the resolution of leukocytosis and eosinophilia.
Implications:
- Systemic eosinophilia warrants consideration of underlying malignancy in differential diagnoses.
- This case underscores the association between uterine leiomyosarcoma and significant eosinophilic infiltration.
- Prompt surgical intervention can resolve tumor-associated eosinophilia.