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Bactericidal/permeability-increasing protein is expressed by human dermal fibroblasts and upregulated by interleukin
Philipp H Reichel1, Christine Seemann, Elena Csernok
1Department of Rheumatology, University Hospital Luebeck and Rheumaklinik Bad Bramstedt, 24576 Bad Bramstedt, Germany.
Clinical and Diagnostic Laboratory Immunology
|May 10, 2003
Abstract:
The bactericidal/permeability-increasing protein (BPI) is an antibiotic- and endotoxin-neutralizing protein of granulocytes and epithelial cells. Constitutive expression of BPI, which increases upon interleukin 4 stimulation, by human dermal fibroblast was demonstrated, suggesting an important role of BPI in gram-negative bacterial clearance and a dampened response to endotoxin in the skin.