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Peripheral T cell lymphoma: The Sheffield Lymphoma Group experience (1977-2001)
R Musson1, C R Radstone, J M Horsman
1YCR Academic Unit of Clinical Oncology, Weston Park Hospital, Sheffield, S10 2SJ, UK.
International Journal of Oncology
|May 10, 2003
Summary
Peripheral T-cell lymphomas (PTCL) are complex non-Hodgkin's lymphomas. Early stage and extranodal PTCL show better treatment response, but outcomes remain unpredictable, requiring further clinical study.
Area of Science:
- Hematology
- Oncology
- Clinical Research
Background:
- Peripheral T-cell lymphomas (PTCL) constitute about 10% of non-Hodgkin's lymphomas.
- PTCL are a diverse group of lymphoid malignancies with varying clinical behaviors.
Purpose of the Study:
- To analyze the presentation, management, outcomes, and prognostic factors in a large cohort of PTCL patients.
- To identify key indicators influencing treatment response and survival in PTCL.
Main Methods:
- Retrospective analysis of 104 consecutive PTCL patients treated between 1977 and 2001.
- Clinical parameters were recorded, and survival analysis was employed to assess prognostic variables.
Main Results:
- The overall complete remission (CR) rate was 59%.
- Stage at diagnosis and extranodal presentation significantly impacted CR rates (81% vs. 43% for early vs. advanced stage; 74% vs. 46% for extranodal vs. nodal).
- Poor prognostic factors included age >60, high-grade histology, B symptoms, nodal presentation, and advanced stage.
Conclusions:
- While prognostic indicators exist for PTCL, the disease course is often unpredictable.
- Further clinical studies are necessary to improve clinical decision-making for individual PTCL cases.