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Highly efficient Lewis acid-catalysed Pictet-Spengler reactions discovered by parallel screening
Natarajan Srinivasan1, A Ganesan
1Combinatorial Centre of Excellence, Department of Chemistry, University of Southampton, Southampton, United Kingdom SO17 1BJ.
Chemical Communications (Cambridge, England)
|May 13, 2003
Abstract:
High yielding Lewis acid-catalysed one-pot Pictet-Spengler reactions of tryptophan methyl ester and tryptamine with aliphatic and aromatic aldehydes were achieved in short reaction times with the aid of microwave irradiation.