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Hyperhomocysteinemia and oxidative stress during dialysis treatment

Paula Garcia Chiarello1, Maria Terezinha I Vannucchi, Hélio Vannucchi

  • 1Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil.

Renal Failure
|May 13, 2003
PubMed

Insights

Dialysis patients often have high homocysteine levels and oxidative stress, increasing risks for vascular and heart disease. These conditions were prevalent in both hemodialysis and peritoneal dialysis groups, suggesting a link to complications.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Biochemistry

Background:

  • Vascular alterations and cardiac diseases are leading causes of mortality in dialysis patients.
  • Hyperhomocysteinemia and oxidative stress are implicated as potential contributing factors.
  • Understanding their prevalence and relationship is crucial for patient outcomes.

Purpose of the Study:

  • To investigate the occurrence of hyperhomocysteinemia.
  • To assess the levels of oxidative stress.
  • To explore the relationship between these conditions in dialysis patients.

Main Methods:

  • Blood samples were collected from patients undergoing hemodialysis (HD) and peritoneal dialysis (PD), as well as healthy controls.
  • Levels of homocysteine, folate, vitamin B12, and antioxidant substances were quantified.
  • Oxidative stress was assessed by measuring the balance between oxidant and antioxidant factors.

Main Results:

  • Hyperhomocysteinemia was detected in all HD patients and 95% of PD patients.
  • Oxidative stress was present in all dialysis patients, being more severe in the HD group.
  • In HD patients, lipoperoxidation and protein oxidation correlated with reduced levels of vitamins E and C.

Conclusions:

  • Both hemodialysis and peritoneal dialysis are associated with hyperhomocysteinemia and oxidative stress.
  • These conditions may play a role in the development of complications in dialysis patients.
  • Further research is warranted to explore therapeutic interventions.
Abstract

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