Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

How long will long-term potentiation last?

Wickliffe C Abraham1

  • 1Department of Psychology, Box 56, University of Otago, Dunedin, New Zealand. cabraham@psy.otaago.ac.nz

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|May 13, 2003
PubMed
Summary

Long-term potentiation (LTP) in the dentate gyrus can persist for months or longer, depending on activity and experience. This finding advances our understanding of memory mechanisms and long-term memory storage.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transregional astrocyte-dependent metaplasticity in the hippocampus.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Clustering Properties of Neuronal Ryanodine Receptor 2 and Remodeling in the APP/PS1 Mouse Model of Alzheimer's Disease.

Acta physiologica (Oxford, England)·2026
Same author

Plasma pTau181 is associated with subjective cognitive concerns but not objective cognitive decline or structural brain integrity measures in midlife.

GeroScience·2026
Same author

The superior colliculus gates dopamine responses to conditioned stimuli in visual classical conditioning.

Nature communications·2026
Same author

Virus-mediated gene transfer of soluble amyloid precursor protein-alpha via systemic injection in a mouse model of Alzheimer's disease.

Gene therapy·2026
Same author

Biomarkers.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025

Area of Science:

  • Neuroscience
  • Cellular and Molecular Biology

Background:

  • Long-term potentiation (LTP) is a key cellular mechanism for memory formation.
  • Previous research established LTP's persistence but lacked recent insights into its regulation and extent.

Purpose of the Study:

  • To investigate the duration and regulation of LTP persistence in the dentate gyrus.
  • To explore how activity and experience influence LTP maintenance for long-term memory.

Main Methods:

  • Analysis of existing literature and recent experimental findings on LTP in the dentate gyrus.
  • Comparative study of decremental versus stable LTP durations.

Main Results:

  • Dentate gyrus LTP exhibits variable persistence: decremental (hours to weeks) or stable (months or longer).
  • LTP persistence is regulated by induction mechanisms and post-induction activity patterns, including natural experiences.

Conclusions:

  • Dentate gyrus LTP serves as a valuable model for studying long-term memory induction, maintenance, and interference.
  • Future research should explore LTP persistence in other brain regions and its correlation with stored information properties.

Related Experiment Videos