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Related Experiment Videos

D-dimer in acute aortic dissection.

Thomas Weber1, Sonja Högler, Johann Auer

  • 1Cardiology Department, General Hospital of the Barmherzigen Schwestern, Wels, Austria. webertom@aon.at

Chest
|May 13, 2003
PubMed
Summary
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Elevated d-dimer levels are highly sensitive for diagnosing acute aortic dissection. A negative d-dimer test can help rule out this serious condition in patients with chest pain.

Area of Science:

  • Cardiovascular Medicine
  • Diagnostic Laboratory Medicine

Background:

  • Laboratory testing has a limited role in diagnosing aortic dissection.
  • D-dimer testing is primarily used to exclude other conditions.

Purpose of the Study:

  • To investigate the relationship between elevated d-dimer levels and acute aortic dissection.
  • To assess the diagnostic utility of d-dimer testing in suspected aortic dissection.

Main Methods:

  • Prospective testing of d-dimer levels in 10 patients with suspected acute aortic dissection.
  • Retrospective analysis of d-dimer levels in 14 patients with confirmed thoracic aortic dissection.
  • Comparison with 35 control patients presenting with acute chest pain of other origins.

Main Results:

Related Experiment Videos

  • D-dimer testing demonstrated 100% sensitivity for detecting acute aortic dissection (positive in all cases).
  • Mean d-dimer levels were significantly elevated (9.4 micro g/mL) in patients with aortic dissection.
  • Higher d-dimer levels showed a trend towards larger dissection extent but did not correlate with patient outcome.

Conclusions:

  • D-dimer testing should be considered in the initial assessment of patients with suspected aortic dissection.
  • A negative d-dimer result is valuable for excluding the diagnosis of aortic dissection.