Modulation of mitogenic activity of fibroblast growth factors by inorganic polyphosphate
Toshikazu Shiba1, Daisuke Nishimura, Yumi Kawazoe
1Frontier Research Division, Fujirebio Inc., 51, Komiya, Hachioji, Tokyo 192-0031, Japan. tz-shiba@fujirebio.co.jp
Abstract:
The proliferation of normal human fibroblast cells was enhanced by the addition of inorganic polyphosphate (poly(P)) into culture media. The mitogenic activities of acidic fibroblast growth factor (FGF-1) and basic fibroblast growth factor (FGF-2) were also enhanced by poly(P). A physical interaction between poly(P) and FGF-2 was observed, and FGF-2 was both physically and functionally stabilized by poly(P). Furthermore, poly(P) facilitated the FGF-2 binding to its cell surface receptors. Because poly(P) is widely distributed in mammalian tissues, it may be a spontaneous modulator of FGFs.
Related Concept Videos
Mitogens and the Cell Cycle
IP3/DAG Signaling Pathway
Amplifying Signals via Second Messengers
Phosphoinositides and PIPs
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
Calmodulin-dependent Signaling
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
What are Second Messengers?


