Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Both electrical and chemical synapses mediate fast network oscillations in the olfactory bulb.

Daniel Friedman1, Ben W Strowbridge

  • 1Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA.

Journal of Neurophysiology
|May 13, 2003
PubMed
Summary

Researchers discovered that the olfactory bulb generates fast brain oscillations by activating inhibitory interneurons. This network synchronization is crucial for processing and discriminating odors.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neural mechanisms of time-forward predictions for naturalistic auditory tone sequences.

Nature communications·2026
Same author

Virtual Responsive Neurostimulation Implantation: From Intracranial Connectivity to Optimized Lead Placement.

medRxiv : the preprint server for health sciences·2026
Same author

A Probabilistic Approach to Functional Organization Based on Extraoperative Electrocortical Stimulation Mapping.

Neurology·2026
Same author

Frontal cortex organization supporting audiovisual processing during naturalistic viewing.

Nature communications·2026
Same author

On-site exposure to clinical epilepsy practice for experimental scientists engaged in epilepsy research: A pilot study by the ILAE commission on neurobiology.

Epilepsia open·2026
Same author

A Phase-2 Open-Label Trial of Cannabidiol to Treat Core and Associated Symptoms of Autism in Children and Adolescents Without Intellectual Disability.

Journal of child and adolescent psychopharmacology·2026

Area of Science:

  • Neuroscience
  • Olfactory System Research

Background:

  • Odor perception involves complex molecular, cellular, and network interactions in olfactory brain areas.
  • Fast (20-70 Hz) brain oscillations are linked to odor perception and discrimination, but their cellular basis is unclear.

Purpose of the Study:

  • To investigate the cellular mechanisms underlying fast network oscillations in the olfactory bulb.
  • To understand how the olfactory bulb generates synchronized neural activity during odor processing.

Main Methods:

  • Used in vitro rat olfactory bulb preparations.
  • Applied brief electrical stimulation to mimic natural sensory input.
  • Utilized intracellular and field recordings, along with pharmacological agents (glutamate-receptor antagonists, gap junction inhibitors).

Related Experiment Videos

Main Results:

  • Electrical stimulation evoked synchronous fast oscillations in the olfactory bulb.
  • Observed periodic inhibitory potentials in mitral cells and prolonged spiking in granule cells.
  • Demonstrated that network synchronization depends on both chemical and electrical synaptic interactions.
  • Showed persistent enhancement of granule cell activity and mitral cell inhibition after repeated stimulation.

Conclusions:

  • The olfactory bulb can autonomously generate fast oscillations via inhibitory interneuron networks.
  • Local circuit interactions within the olfactory bulb are critical for generating high-frequency network activity.
  • These findings provide insights into the neural basis of odor processing and discrimination.