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Updated: Sep 26, 2026

Intermittent Binge-Intake Model in Mice
Published on: January 10, 2025
Effects of sibutramine on binge eating, hunger, and fullness in a laboratory human feeding paradigm
James E Mitchell1, Blake A Gosnell, James L Roerig
1The Neuropsychiatric Research Institute and the University of North Dakota School of Medicine and Health Sciences, Fargo, North Dakota, USA. mitchell@medicine.nodak.edu
Objective:
The purpose of this study was to evaluate the effects of sibutramine vs. placebo on binge-eating behavior, hunger, and satiety in patients who had problems with binge eating.
Research Methods And Procedures:
Seven adult subjects who had problems with binge eating (mean age, 42 years) were randomly assigned to receive alternating sibutramine and placebo in a double-blind placebo-controlled crossover study. This involved two 4-week dosing periods separated by a 2-week washout.
Results:
Subjects lost weight on sibutramine but not on placebo. There was a significant difference in the number of kilocalories consumed between the sibutramine and placebo conditions, with a significant reduction of intake during binge-eating episodes on sibutramine.
Discussion:
Sibutramine suppresses intake during binge-eating episodes. This effect is demonstrable in a human feeding laboratory paradigm.
Related Concept Videos
Binge Eating Disorders
Regulation of Food Intake
