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Expression of p65, DD3 and c-erbB2 genes in prostate cancer
E Balcerczak1, M Mirowski, A Sasor
1Department of Pharmaceutical Biochemistry; Molecular Biology Laboratory, 90-151 Lodz, Poland.
Abstract:
The expression of p65, DD3 and c-erbB2 genes was analyzed in 39 histologically verified human prostate cancers. The expression of p65 and DD3 genes was observed in significant percentage in well- and moderately-differentiated tumors. Both genes expression was lower in poorly differentiated tumors. On the contrary, c-erbB2 gene expression increased with advanced histological grading and reached the highest percentage in poorly-differentiated cancers. In the all investigated groups straight dependence between p65 and DD3 genes expression occurred. Opposite dependence was noticed in expression of p65/DD3 and c-erbB2 genes.