Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Peroxisome assembly in yeast.

Marten Veenhuis1, Jan A K W Kiel, Ida J Van Der Klei

  • 1Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, NL-9750 AA Haren, The Netherlands. M.Veenhuis@biol.rug.nl

Microscopy Research and Technique
|May 13, 2003
PubMed
Summary

This review discusses recent findings on how peroxisomes form in yeast. Traditionally, peroxisomes were thought to develop by growing and splitting from existing ones. New evidence suggests they may instead come from the endomembrane system, changing based on environmental needs. The authors also summarize progress in understanding how proteins get into peroxisomes. This work proposes a revised model of peroxisome biogenesis that includes alternative formation methods and dynamic regulation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The peroxisomal importomer can accommodate an intrinsically disordered protein of 1247 residues.

Histochemistry and cell biology·2026
Same author

Peroxisome deficiency impacts metabolites of lysine, lipid, and polyamine metabolism in Saccharomyces cerevisiae.

Histochemistry and cell biology·2026
Same author

Competition between binding partners of yeast Pex3 affects peroxisome biology.

The FEBS journal·2025
Same author

Protocol for the colocalization of yeast peroxisomal membrane proteins and their binding partners using stimulated emission depletion microscopy.

STAR protocols·2025
Same author

Docosahexaenoic acid prevents peroxisomal and mitochondrial protein loss in a murine hepatic organoid model of severe malnutrition.

Biochimica et biophysica acta. Molecular basis of disease·2025
Same author

Artificial ER-Mitochondrion Tethering Restores Erg6 Localization and Lipid Droplet Formation in <i>Hansenula polymorpha Δpex23</i> and <i>Δpex29</i> Cells.

Contact (Thousand Oaks (Ventura County, Calif.))·2025

Area of Science:

  • Cell biology within organelle biogenesis
  • Molecular genetics in yeast models
  • Eukaryotic cell structure and function

Background:

Peroxisomes have long been considered static organelles that develop through growth and fission from existing structures. However, recent findings suggest peroxisomes may be dynamic and part of the endomembrane system. Prior research has shown peroxisomes perform functions that vary with organism, cell type, and environment. This uncertainty drove the need to reassess peroxisome biogenesis mechanisms. No prior work had resolved whether peroxisomes form through alternative pathways. The absence of clear evidence for alternative assembly routes motivated further investigation. This gap motivated researchers to examine recent data on peroxisome formation. That uncertainty drove a synthesis of current knowledge on peroxisome assembly.

Purpose Of The Study:

The purpose of this review is to summarize recent findings on peroxisome biogenesis in yeast. It aims to clarify whether peroxisomes form via growth and fission or alternative methods. The study also seeks to examine how peroxisomal matrix proteins are imported into the organelle. This work addresses a gap in understanding peroxisome formation and protein import. The authors propose that peroxisomes may arise from the endomembrane system under environmental cues. They also aim to highlight progress in understanding the matrix protein import machinery. This paper provides a synthesis of recent evidence on peroxisome assembly mechanisms. The authors suggest that peroxisomes may be more dynamic than previously thought.

Keywords:
organelle formationyeast cell biologyendomembrane systemmatrix protein import

Frequently Asked Questions

The authors propose that peroxisomes may arise from the endomembrane system, not only through growth and fission.

The review suggests peroxisomes may form independently of pre-existing organelles under environmental cues.

Recent evidence indicates peroxisomes may originate from the endomembrane system in response to environmental demands.

The review discusses progress in understanding how matrix proteins are imported into peroxisomes.

Related Experiment Videos

Main Methods:

This review paper synthesizes recent experimental and observational data on peroxisome biogenesis. The authors analyze evidence from yeast studies to assess peroxisome formation mechanisms. They examine whether peroxisomes arise from pre-existing organelles or alternative sources. The review includes findings on the dynamic nature of peroxisomes and their response to environmental changes. The authors assess the role of the endomembrane system in peroxisome assembly. They also evaluate data on alternative pathways for peroxisome formation. The review discusses progress in understanding the peroxisomal matrix protein import process. The authors synthesize literature to propose updated models of peroxisome biogenesis.

Main Results:

Recent evidence suggests peroxisomes may arise from the endomembrane system in response to environmental demands. This finding challenges the traditional view of peroxisome formation through growth and fission. The authors propose that peroxisomes may be a dynamic population of organelles. Alternative methods of peroxisome formation are now supported by accumulating data. The review highlights progress in understanding the peroxisomal matrix protein import machinery. Key findings suggest that peroxisomes may be generated independently of pre-existing organelles. The evidence indicates that peroxisome biogenesis is more flexible than previously assumed. The authors summarize recent data that supports a revised model of peroxisome formation.

Conclusions:

The authors conclude that peroxisomes may be part of the endomembrane system and are dynamic. They suggest that peroxisomes may arise and be removed based on environmental needs. The review proposes that peroxisomes may form through alternative methods beyond growth and fission. The authors summarize recent findings on peroxisome biogenesis in yeast. They highlight progress in understanding the matrix protein import machinery. The review suggests that peroxisomes are more flexible in their formation than previously thought. The authors propose that peroxisome assembly is influenced by environmental and developmental factors. This synthesis supports a revised model of peroxisome biogenesis based on recent evidence.

Environmental changes may trigger peroxisome assembly or removal, indicating dynamic regulation.

The authors suggest peroxisomes may be more dynamic and adaptable than previously assumed.